Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA

[Image: see text] Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the function of fitness (e.g., catalytic activity) over the space of all possible sequences. Understanding evolution requires knowing the structure of the fitness landscape and identifying the viable...

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Detalles Bibliográficos
Autores principales: Pressman, Abe D., Liu, Ziwei, Janzen, Evan, Blanco, Celia, Müller, Ulrich F., Joyce, Gerald F., Pascal, Robert, Chen, Irene A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548421/
https://www.ncbi.nlm.nih.gov/pubmed/30912655
http://dx.doi.org/10.1021/jacs.8b13298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548421/
https://www.ncbi.nlm.nih.gov/pubmed/30912655
http://dx.doi.org/10.1021/jacs.8b13298

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