Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells

Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote...

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Detalles Bibliográficos
Autores principales: Pasero, Philippe, Tourrière, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548472/
https://www.ncbi.nlm.nih.gov/pubmed/31211234
http://dx.doi.org/10.1080/23723556.2019.1607455
Descripción
Sumario:Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote fork progression in a checkpoint-independent manner.

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