Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells

Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote...

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Detalles Bibliográficos
Autores principales: Pasero, Philippe, Tourrière, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548472/
https://www.ncbi.nlm.nih.gov/pubmed/31211234
http://dx.doi.org/10.1080/23723556.2019.1607455
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author Pasero, Philippe
Tourrière, Hélène
author_facet Pasero, Philippe
Tourrière, Hélène
author_sort Pasero, Philippe
collection PubMed
description Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote fork progression in a checkpoint-independent manner.
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spelling pubmed-65484722020-05-07 Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells Pasero, Philippe Tourrière, Hélène Mol Cell Oncol Author's Views Oncogene-induced replication stress (RS) plays an active role in tumorigenesis by promoting genomic instability but is also a challenge for cell proliferation. Recent evidence indicates that different types of cancer cells adapt to RS by overexpressing components of the ATR-CHK1 pathway that promote fork progression in a checkpoint-independent manner. Taylor & Francis 2019-05-07 /pmc/articles/PMC6548472/ /pubmed/31211234 http://dx.doi.org/10.1080/23723556.2019.1607455 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Pasero, Philippe
Tourrière, Hélène
Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title_full Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title_fullStr Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title_full_unstemmed Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title_short Overexpression of the Fork Protection Complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
title_sort overexpression of the fork protection complex: a strategy to tolerate oncogene-induced replication stress in cancer cells
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548472/
https://www.ncbi.nlm.nih.gov/pubmed/31211234
http://dx.doi.org/10.1080/23723556.2019.1607455
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