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Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism
CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic analyses of the CHC22-encoding CLTCL1 gene, revealing independent gene loss in at least two vertebrate lineages, after ari...
Autores principales: | Fumagalli, Matteo, Camus, Stephane M, Diekmann, Yoan, Burke, Alice, Camus, Marine D, Norman, Paul J, Joseph, Agnel, Abi-Rached, Laurent, Benazzo, Andrea, Rasteiro, Rita, Mathieson, Iain, Topf, Maya, Parham, Peter, Thomas, Mark G, Brodsky, Frances M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548504/ https://www.ncbi.nlm.nih.gov/pubmed/31159924 http://dx.doi.org/10.7554/eLife.41517 |
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