Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes

Irbesartan has shown significant therapeutic effects in hypertensive patients with non-alcoholic fatty liver disease (NAFLD). To determine the underlying mechanisms of its action, we established an in vitro model of NAFLD by treating human and mouse hepatocytes with free fatty acids (FFAs) and angio...

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Detalles Bibliográficos
Autores principales: He, Juan, Ding, Jian, Lai, Qiuhua, Wang, Xinke, Li, Aimin, Liu, Side
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548903/
https://www.ncbi.nlm.nih.gov/pubmed/31191364
http://dx.doi.org/10.3389/fphys.2019.00681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548903/
https://www.ncbi.nlm.nih.gov/pubmed/31191364
http://dx.doi.org/10.3389/fphys.2019.00681

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