Cargando…

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes

Irbesartan has shown significant therapeutic effects in hypertensive patients with non-alcoholic fatty liver disease (NAFLD). To determine the underlying mechanisms of its action, we established an in vitro model of NAFLD by treating human and mouse hepatocytes with free fatty acids (FFAs) and angio...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Juan, Ding, Jian, Lai, Qiuhua, Wang, Xinke, Li, Aimin, Liu, Side
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548903/ https://www.ncbi.nlm.nih.gov/pubmed/31191364 http://dx.doi.org/10.3389/fphys.2019.00681

Ejemplares similares

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells
por: Wang, Xinke, et al.
Publicado: (2019)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

Role of AMPK in autophagy
por: Wang, Shengyuan, et al.
Publicado: (2022)

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle
por: Drake, Joshua C., et al.
Publicado: (2021)

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy
por: Song, Jia, et al.
Publicado: (2023)

Tangshen Decoction Enhances Podocytes Autophagy to Relieve Diabetic Nephropathy through Modulation of p-AMPK/p-ULK1 Signaling
por: Yan, Ling, et al.
Publicado: (2022)

Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis
por: Che, Lixiao, et al.
Publicado: (2019)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

The AMPK pathway in fatty liver disease
por: Fang, Chunqiu, et al.
Publicado: (2022)

iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
por: Cen, Haimei, et al.
Publicado: (2023)

Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation
por: Wang, Qinglan, et al.
Publicado: (2020)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
por: Lu, Qing-Bo, et al.
Publicado: (2022)

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
por: Fan, Xue-Yu, et al.
Publicado: (2015)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

STAT3 suppresses the AMPKα/ULK1‐dependent induction of autophagy in glioblastoma cells
por: Bhattacharya, Sujoy, et al.
Publicado: (2022)

AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells
por: Bu, Heqi, et al.
Publicado: (2020)

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
por: Yuan, Jie, et al.
Publicado: (2018)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation
por: Holczer, Marianna, et al.
Publicado: (2020)

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
por: Ma, Teng, et al.
Publicado: (2022)

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis
por: Iorio, Roberto, et al.
Publicado: (2021)

Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy
por: Xiao, Qiang, et al.
Publicado: (2020)

Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway
por: Liu, Xiao Yan, et al.
Publicado: (2022)

Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway
por: Jia, Lei, et al.
Publicado: (2022)

Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells
por: Heng, Yongqing, et al.
Publicado: (2021)

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells
por: Zhang, Yan, et al.
Publicado: (2021)

Qiangjing tablets ameliorate asthenozoospermia via mitochondrial ubiquitination and mitophagy mediated by LKB1/AMPK/ULK1 signaling
por: Li, Guangsen, et al.
Publicado: (2023)

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
por: Lin, Chenchu, et al.
Publicado: (2021)

Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation
por: Dusabimana, Theodomir, et al.
Publicado: (2021)

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma
por: Pan, Zhen, et al.
Publicado: (2023)

Human milk oligosaccharide 2'-fucosyllactose promotes melanin degradation via the autophagic AMPK–ULK1 signaling axis
por: Heo, Hyojin, et al.
Publicado: (2022)

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
por: Wang, Yan, et al.
Publicado: (2019)

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury
por: Wang, Ying, et al.
Publicado: (2020)

The mammalian ULK1 complex and autophagy initiation
por: Zachari, Maria, et al.
Publicado: (2017)

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy
por: Zhao, Wenyu, et al.
Publicado: (2018)

Icariin Inhibits AMPK-Dependent Autophagy and Adipogenesis in Adipocytes In vitro and in a Model of Graves' Orbitopathy In vivo
por: Li, Hong, et al.
Publicado: (2017)

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy
por: Fan, Kerui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_u9595j3vacc23n0bqvopaulo34