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RGD-independent binding of Russell’s Viper venom Kunitz-type protease inhibitors to platelet GPIIb/IIIa receptor

This study elucidates the platelet-modulating properties of two snake venom Kunitz-type serine protease inhibitors, Rusvikunin and Rusvikunin-II, from Russell’s Viper venom, their native and reconstituted complexes, and two synthetic custom peptides (developed from the platelet-binding region of Rus...

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Detalles Bibliográficos
Autores principales: Kalita, Bhargab, Dutta, Sumita, Mukherjee, Ashis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549151/
https://www.ncbi.nlm.nih.gov/pubmed/31165757
http://dx.doi.org/10.1038/s41598-019-44767-2