Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation

BACKGROUND: Vascular maturity and functionality are closely associated with tumor progression and chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast cancer models. However, it remains unclear if or how metformin remodels the ab...

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Detalles Bibliográficos
Autores principales: Wang, Ji-Chang, Li, Guang-Yue, Wang, Bo, Han, Su-Xia, Sun, Xin, Jiang, Yi-Na, Shen, Yan-Wei, Zhou, Can, Feng, Jun, Lu, Shao-Ying, Liu, Jian-Lin, Wang, Mao-De, Liu, Pei-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549289/
https://www.ncbi.nlm.nih.gov/pubmed/31164151
http://dx.doi.org/10.1186/s13046-019-1211-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549289/
https://www.ncbi.nlm.nih.gov/pubmed/31164151
http://dx.doi.org/10.1186/s13046-019-1211-2

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