In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model

The low response rate of immune checkpoint blockade in breast cancer has highlighted the need for predictive biomarkers to identify responders. While a number of clinical trials are ongoing, testing all possible combinations is not feasible. In this study, a quantitative systems pharmacology model i...

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Detalles Bibliográficos
Autores principales: Wang, Hanwen, Milberg, Oleg, Bartelink, Imke H., Vicini, Paolo, Wang, Bing, Narwal, Rajesh, Roskos, Lorin, Santa-Maria, Cesar A., Popel, Aleksander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Biochemistry and Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549962/
https://www.ncbi.nlm.nih.gov/pubmed/31218069
http://dx.doi.org/10.1098/rsos.190366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549962/
https://www.ncbi.nlm.nih.gov/pubmed/31218069
http://dx.doi.org/10.1098/rsos.190366

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