Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization and aggregation of which are key pathological fea...

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Detalles Bibliográficos
Autores principales: Jiang, Tongcui, Handley, Emily, Brizuela, Mariana, Dawkins, Edgar, Lewis, Katherine E. A., Clark, Rosemary M., Dickson, Tracey C., Blizzard, Catherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550035/
https://www.ncbi.nlm.nih.gov/pubmed/31036551
http://dx.doi.org/10.1242/dmm.038109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550035/
https://www.ncbi.nlm.nih.gov/pubmed/31036551
http://dx.doi.org/10.1242/dmm.038109

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