Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response

The purpose of study was to explore the role of glutamine-dependent anaplerosis in cell fate determination (proliferation and senescence) and the potential associated mechanism by employing a pharmacological inhibitor of glutamine-dependent anaplerosis, amino-oxyacetate (AOA). Using the WI38 normal...

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Detalles Bibliográficos
Autores principales: Liao, Geng-You, Lee, Ming-Ting, Fan, Jhen-Jia, Hsiao, Pei-Wen, Lee, Chun-Sheng, Su, Shou-Yi, Hwang, Jiuan-Jiuan, Ke, Ferng-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550068/
https://www.ncbi.nlm.nih.gov/pubmed/31097446
http://dx.doi.org/10.1242/bio.038257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550068/
https://www.ncbi.nlm.nih.gov/pubmed/31097446
http://dx.doi.org/10.1242/bio.038257

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