Cargando…

PGC1α/CEBPB/CPT1A axis promotes radiation resistance of nasopharyngeal carcinoma through activating fatty acid oxidation

The PPAR coactivator‐1α (PGC1α) is an important transcriptional co‐activator in control of fatty acid metabolism. Mitochondrial fatty acid oxidation (FAO) is the primary pathway for the degradation of fatty acids and promotes NADPH and ATP production. Our previous study demonstrated that upregulatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Qianqian, Tan, Zheqiong, Shi, Feng, Tang, Min, Xie, Longlong, Zhao, Lin, Li, Yueshuo, Hu, Jianmin, Zhou, Min, Bode, Ann, Luo, Xiangjian, Cao, Ya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550130/ https://www.ncbi.nlm.nih.gov/pubmed/30945396 http://dx.doi.org/10.1111/cas.14011

Ejemplares similares

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy
por: Tan, Zheqiong, et al.
Publicado: (2018)

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma
por: Tang, Min, et al.
Publicado: (2022)

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination
por: Liu, Xiaolan, et al.
Publicado: (2018)

Anoikis resistance and immune escape mediated by Epstein-Barr virus-encoded latent membrane protein 1-induced stabilization of PGC-1α promotes invasion and metastasis of nasopharyngeal carcinoma
por: Liao, Chaoliang, et al.
Publicado: (2023)

Nintedanib Alleviates Experimental Colitis by Inhibiting CEBPB/PCK1 and CEBPB/EFNA1 Pathways
por: Li, Hailong, et al.
Publicado: (2022)

A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer
por: Hu, Anni, et al.
Publicado: (2023)

Posttranslational regulation of PGC‐1α and its implication in cancer metabolism
por: Luo, Xiangjian, et al.
Publicado: (2019)

Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy
por: Hu, Jianmin, et al.
Publicado: (2020)

Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy: Erratum
por: Hu, Jianmin, et al.
Publicado: (2022)

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study
por: Cao, Ya, et al.
Publicado: (2021)

Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib
por: Vidarsdottir, Linda, et al.
Publicado: (2020)

Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1
por: Zhao, Lin, et al.
Publicado: (2021)

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance
por: Xie, Longlong, et al.
Publicado: (2020)

Correction: Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance
por: Xie, Longlong, et al.
Publicado: (2022)

The Role of Deubiquitinases in Oncovirus and Host Interactions
por: Li, Yueshuo, et al.
Publicado: (2019)

(−)-Epigallocatechin-3-Gallate Inhibits EBV Lytic Replication via Targeting LMP1-Mediated MAPK Signal Axes
por: Li, Hongde, et al.
Publicado: (2021)

MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer
por: Wu, Honglei, et al.
Publicado: (2020)

PRPF6 promotes metastasis and paclitaxel resistance of ovarian cancer via SNHG16/CEBPB/GATA3 axis
por: WANG, HAN, et al.
Publicado: (2022)

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter
por: Shi, Feng, et al.
Publicado: (2019)

Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF-MMP2/CD44 axes
por: Luo, Xiangjian, et al.
Publicado: (2016)

Mitochondrial network structure homeostasis and cell death
por: Xie, Long‐long, et al.
Publicado: (2018)

Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
por: Li, Jiangjiang, et al.
Publicado: (2018)

PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes
por: Angelini, Aude, et al.
Publicado: (2021)

PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway
por: Liu, Min, et al.
Publicado: (2022)

Prospective signs of cleidocranial dysplasia in Cebpb deficiency
por: Huang, Boyen, et al.
Publicado: (2014)

Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling
por: Wang, Xiaoyang, et al.
Publicado: (2022)

Wild-type IDH2 contributes to Epstein–Barr virus-dependent metabolic alterations and tumorigenesis
por: Shi, Feng, et al.
Publicado: (2020)

Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication
por: Li, Yueshuo, et al.
Publicado: (2021)

Quantitative proteomics reveals Polygonum perfoliatum L. ameliorates hepatic steatosis by promoting PPARs/CPT1A/CPT2-mediated fatty acid β-oxidation
por: Liu, Guanjie, et al.
Publicado: (2023)

CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis: CPT1C promotes CRC progression
por: Li, Jing, et al.
Publicado: (2023)

NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation: NQO1/CPT1A promotes PAAD via FAO
por: Xu, Ran, et al.
Publicado: (2023)

The PGC-1/ERR network and its role in precision oncology
por: De Vitto, Humberto, et al.
Publicado: (2019)

Emerging roles of lipid metabolism in cancer metastasis
por: Luo, Xiangjian, et al.
Publicado: (2017)

Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis
por: Zhou, Zili, et al.
Publicado: (2022)

IDH2 is a novel diagnostic and prognostic serum biomarker for non‐small‐cell lung cancer
por: Li, Jiang‐jiang, et al.
Publicado: (2018)

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma
por: Yang, Lifang, et al.
Publicado: (2015)

DNMT1 mediates metabolic reprogramming induced by Epstein–Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma
por: Luo, Xiangjian, et al.
Publicado: (2018)

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA
por: Ngo, Jennifer, et al.
Publicado: (2023)

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
por: Viscomi, Carlo, et al.
Publicado: (2011)

HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
por: Guo, Xin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lhg1oqo89757bnnagt9gt2jb0v