Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development

Dominant mutations of Gata4, an essential cardiogenic transcription factor (TF), were known to cause outflow tract (OFT) defects in both human and mouse, but the underlying molecular mechanism was not clear. In this study, Gata4 haploinsufficiency in mice was found to result in OFT defects including...

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Detalles Bibliográficos
Autores principales: Liu, Jielin, Cheng, Henghui, Xiang, Menglan, Zhou, Lun, Wu, Bingruo, Moskowitz, Ivan P., Zhang, Ke, Xie, Linglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550424/
https://www.ncbi.nlm.nih.gov/pubmed/31120883
http://dx.doi.org/10.1371/journal.pgen.1007711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550424/
https://www.ncbi.nlm.nih.gov/pubmed/31120883
http://dx.doi.org/10.1371/journal.pgen.1007711

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