Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A. fumigatus clinical isolates from patients failing echinocand...

Descripción completa

Detalles Bibliográficos
Autores principales: Satish, Shruthi, Jiménez-Ortigosa, Cristina, Zhao, Yanan, Lee, Min Hee, Dolgov, Enriko, Krüger, Thomas, Park, Steven, Denning, David W., Kniemeyer, Olaf, Brakhage, Axel A., Perlin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550521/
https://www.ncbi.nlm.nih.gov/pubmed/31164462
http://dx.doi.org/10.1128/mBio.00779-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550521/
https://www.ncbi.nlm.nih.gov/pubmed/31164462
http://dx.doi.org/10.1128/mBio.00779-19

Ejemplares similares