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MON-481 MA-[D-Leu-4]-OB3, a Small Molecule Synthetic Peptide Leptin Mimetic, Enhances the Effects of Insulin on Glycemic Control and Cognitive Function in Streptozotocin-Induced Hyperglycemic Swiss Webster Mice

Glucose dysregulation and disruption of insulin signaling in the brain have been suggested as a possible etiology of Alzheimer’s Disease. In the present study, we show that oral delivery of MA-[D-Leu-4]-OB3 to young male Swiss Webster (SW) mice rendered hyperglycemic by intraperitoneal injection of...

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Detalles Bibliográficos
Autores principales: Anderson, Brian, Wang, Guirong, Novakovic, Zachary, Grasso, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550609/
http://dx.doi.org/10.1210/js.2019-MON-481