MON-475 Growth Hormone Induces Colon Tissue DNA Damage Independently of IGF-1

Environmental insults and aging lead to DNA damage, which, if unrepaired, results in chromosomal instability and tumorigenesis. We have shown that GH suppresses phosphorylation of ATM and its target proteins p53, Chk2, and H2AX in DNA damaged non-tumorous human colon cells. We show that GH decreased...

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Detalles Bibliográficos
Autores principales: Chesnokova, Vera, Zonis, Svetlana, Barrett, Robert, Gleeson, John, Gorbunova, Vera, Melmed, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
http://dx.doi.org/10.1210/js.2019-MON-475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550948/
http://dx.doi.org/10.1210/js.2019-MON-475

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