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The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist
The mouse X-inactivation center (Xic) locus represents a powerful model for understanding the links between genome architecture and gene regulation, with the non-coding genes Xist and Tsix showing opposite developmental expression patterns while being organized as an overlapping sense/antisense unit...
Autores principales: | van Bemmel, Joke G., Galupa, Rafael, Gard, Chris, Servant, Nicolas, Picard, Christel, Davies, James, Szempruch, Anthony James, Zhan, Yinxiu, Żylicz, Jan J., Nora, Elphège P., Lameiras, Sonia, de Wit, Elzo, Gentien, David, Baulande, Sylvain, Giorgetti, Luca, Guttman, Mitchell, Hughes, Jim R., Higgs, Douglas R., Gribnau, Joost, Heard, Edith |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551226/ https://www.ncbi.nlm.nih.gov/pubmed/31133748 http://dx.doi.org/10.1038/s41588-019-0412-0 |
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