mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation

Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by mutant IDH1/2 (mIDH1/2), has been suggested to p...

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Detalles Bibliográficos
Autores principales: Wiehle, Laura, Raddatz, Günter, Pusch, Stefan, Gutekunst, Julian, von Deimling, Andreas, Rodríguez-Paredes, Manuel, Lyko, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551656/
https://www.ncbi.nlm.nih.gov/pubmed/31225434
http://dx.doi.org/10.15698/cst2017.10.106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551656/
https://www.ncbi.nlm.nih.gov/pubmed/31225434
http://dx.doi.org/10.15698/cst2017.10.106

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