The NLRC4 inflammasome requires IRF8-dependent production of NAIPs

Activation of the NLRC4 inflammasome is crucial for defense against bacterial species that have flagellin or the type III secretion system (T3SS). We have discovered the role of interferon regulatory factor 8 (IRF8) in mediating NLRC4 inflammasome activation. IRF8 is required for the transcription o...

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Detalles Bibliográficos
Autores principales: Lee, Ein, Karki, Rajendra, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2018
Materias:
Microreview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551684/
https://www.ncbi.nlm.nih.gov/pubmed/31225480
http://dx.doi.org/10.15698/cst2018.06.141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551684/
https://www.ncbi.nlm.nih.gov/pubmed/31225480
http://dx.doi.org/10.15698/cst2018.06.141

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