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SAT-LB072 Pharmacological Chaperone Rescue of Function in Human HPG Axis GPCRs with Inactivating Mutations

Inactivating mutations in G-protein coupled receptors (GPCRs) at all levels of the HPG axis give rise to incomplete reproductive development and adult infertility. The majority of the mutations in GPCRs cause misfolding of the receptor and a failure to traffic to the cell surface. We have identified...

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Detalles Bibliográficos
Autor principal: Millar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552011/
http://dx.doi.org/10.1210/js.2019-SAT-LB072