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SAT-LB072 Pharmacological Chaperone Rescue of Function in Human HPG Axis GPCRs with Inactivating Mutations
Inactivating mutations in G-protein coupled receptors (GPCRs) at all levels of the HPG axis give rise to incomplete reproductive development and adult infertility. The majority of the mutations in GPCRs cause misfolding of the receptor and a failure to traffic to the cell surface. We have identified...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Endocrine Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552011/ http://dx.doi.org/10.1210/js.2019-SAT-LB072 |