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SAT-344 11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrgenase Inhibitor, Is Metabolised In Vitro by Adrenal Steroidogenic Enzymes

The C11-oxy C(21) steroids, 11αOHP4 (11α-hydroxyprogesterone) and 11βOHP4 (11β-hydroxyprogesterone), have to date been characterised only in terms of their inhibition of 11β-hydroxysteroid dehydrogenase (11βHSD). However, 11βOHP4 is also a substrate of 11βHSD2 and is converted to 11-ketoprogesterone...

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Detalles Bibliográficos
Autores principales: Gent, Rachelle, Swart, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552517/
http://dx.doi.org/10.1210/js.2019-SAT-344