SUN-LB055 Targeting Mutant p53 Alone or in Combination with a Phosphatidylserine Specific Antibody Suppresses Growth and Metastasis of Human Breast Cancer: A Strategy Towards Enhancing Personalized Medicine

Mutations in the tumor suppressor p53 gene are frequently associated with various cancers, including human breast cancer. Unlike wild-type p53 (wtp53), mutant p53 protein (mtp53) fails to promote apoptosis, resulting in tumor cell survival and resistance to chemotherapeutic drugs. Consequently, rest...

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Detalles Bibliográficos
Autores principales: Liang, Yayun, Besch-Williford, Cynthia, Belenchia, Anthony, Brekken, Rolf, Hyder, Salman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553059/
http://dx.doi.org/10.1210/js.2019-SUN-LB055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553059/
http://dx.doi.org/10.1210/js.2019-SUN-LB055

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