Cargando…

SUN-096 Hypothalamic ATP Has a Crucial Role in the Pathogenesis of Leptin Resistance: A Potential Mechanism for the Amelioration of Leptin Resistance by Celastrol and Withaferin A

Leptin is an adipocyte-derived hormone involved in the regulation of food intake and energy expenditure. Since obese subjects generally have leptin resistance, leptin sensitizers are expected as anti-obesity drugs. It has been reported that endoplasmic reticulum (ER) stress in the hypothalamus plays...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ebihara, Chihiro, Ebihara, Ken, Isoda, Masayo, Murakami, Akiko, Takahashi, Manabu, Nagashima, Shuuichi, Ishibashi, Shun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Adipose Tissue, Appetite, and Obesity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553405/ http://dx.doi.org/10.1210/js.2019-SUN-096

Ejemplares similares

FRI069 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Weight And Associated Comorbidities In Congenital Leptin Deficiency
por: Ozsu, Elif, et al.
Publicado: (2023)

OR12-1 Leptin Is Transported across the Mouse Placenta
por: Park, Soyoung, et al.
Publicado: (2019)

Leptin Decreases Energy Expenditure but Increases Thyroid Hormone in Patients With Lipodystrophy
por: Quaye, Emmanuel, et al.
Publicado: (2021)

LBSUN131 Leptin Level, BMI And Genetics In Early Onset Obesity
por: Xu, Xu, et al.
Publicado: (2022)

FRI039 Endothelial Dysfunction Is Associated With Adiponectin And Leptin In Adolescents With PCOS
por: Gavryutina, Irina, et al.
Publicado: (2023)

MON-096 Body Composition in Patients with Craniopharyngioma: Is DXA-Scanning Necessary for Evaluating the Metabolic Syndrome?
por: van Santen, Selveta, et al.
Publicado: (2019)

SAT-604 The Role of the Focal Adhesion Kinase Family in Leptin Receptor Signaling
por: Hadley, Colleen, et al.
Publicado: (2020)

PSUN100 What Determines Leptin Levels: Moving Beyond Fat Mass
por: Rosenberg, Drake, et al.
Publicado: (2022)

SAT-096 Later Timing of Energy Intake Associates with Higher Fat Mass in Adults with Overweight and Obesity
por: Zaman, Adnin, et al.
Publicado: (2019)

RF12 | PSUN125 Lymphoma in Congenital Leptin Deficiency: Comorbidity or Adverse Effect?
por: Torchen, Laura, et al.
Publicado: (2022)

OR33-03 Congenital Leptin Deficiency: Clinical Insights from the First Reported US Cases
por: Torchen, Laura C, et al.
Publicado: (2020)

RF24 | PSUN127 Congenital Leptin Deficiency: Metabolic, Reproductive, and Psychological Impacts of Therapy
por: Torchen, Laura, et al.
Publicado: (2022)

Severe Early-Onset Obesity in Three Adult Patients Harboring Inactivating Mutations of the Leptin Receptor Gene
por: Chaves, Carolina Marques, et al.
Publicado: (2021)

SAT-595 Early Weight Gain Impact onto the Arcuate Leptin Receptor Expressing Neurons Activity During Development
por: Zampieri, Thais T, et al.
Publicado: (2020)

OR33-02 The Treatment of Partial Lipodystrophy in the Setting of Neutralizing Antibody Against Metreleptin with Leptin Receptor Agonist REGN4461
por: Akinci, Baris, et al.
Publicado: (2020)

FRI057 Drug Concentrations And Dosing Considerations For Mibavademab, A Novel Leptin Receptor Agonist, In Individuals With Generalized Lipodystrophy
por: Mendell, Jeanne, et al.
Publicado: (2023)

FRI059 Long-term Follow-up On Partial Lipodystrophy Treated With Leptin Receptor Agonist Mibavademab(REGN4461)
por: Foss de Freitas, Maria Cristina, et al.
Publicado: (2023)

MON-596 Effects of Angiotensin Type 1 Receptor Blockers (ARBs) on the Expression and Secretion of Adiponectin and Leptin in Human White Adipocytes
por: Hattori, Naoki, et al.
Publicado: (2020)

FRI058 Treatment With Mibavademab, A Novel Leptin Receptor Agonist, Is Associated With Improvement In Metabolic Parameters In Individuals With Generalized Lipodystrophy
por: Olenchock, Ben, et al.
Publicado: (2023)

Serotonin as a Regulator of Leptin-Mediated Food Intake Control Within a Novel Neuronal Circuit Between the Hypothalamus and Raphe Nuclei
por: Sadek, Alia T, et al.
Publicado: (2021)

RF12 | PSUN105 Cord Blood Leptin and Childhood Adiposity Outcomes in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study
por: DeLacey, Sean, et al.
Publicado: (2022)

FRI031 A Novel Strategy To Detect Leptin Receptor (Lepr, fa) Mutation In Obesity And Diabetic Animal Model (Zucker Rats)
por: Xu, Xinyun, et al.
Publicado: (2023)

OR12-6 Deletion Of The Brain-Specific α And δ Isoforms Of SH2B1 Protects Against Diet-Induced Obesity In A Leptin-Independent Manner
por: Cote, Jessica, et al.
Publicado: (2019)

FRI008 Impact Of Sleep Fragmentation And Estradiol Suppression On Leptin, Ghrelin, Satiety And Hunger In Women: An Experimental Menopause Model To Understand Menopause-related Body Fat Gain
por: Rahman, Shadab A, et al.
Publicado: (2023)

OR01-5 Leptin Acts through Altering Energy Intake and Lipolysis to Reduce Body Weight but Has No Effect on Energy Expenditure, Physical Activity, and Sympathetic Nervous System in Humans
por: Chrysafi, Pavlina, et al.
Publicado: (2019)

Dextroamphetamine Treatment for Children With Hypothalamic Obesity
por: van Schaik, Jiska, et al.
Publicado: (2021)

Hypothalamic Glucagon Receptors Regulate Feeding in Mice
por: Cunningham, Stephen E, et al.
Publicado: (2021)

SUN-101 Dysregulation of Hypothalamic Gene Expression by Soybean Oil Diets in Mice
por: Deol, Poonamjot, et al.
Publicado: (2019)

Weight Loss, Improved Body Composition and Fat Distribution by Tesomet in Acquired Hypothalamic Obesity
por: Huynh, Kim D, et al.
Publicado: (2021)

FRI082 Impact Of Setmelanotide On Metabolic Parameters And Vital Signs In Patients With Hypothalamic Obesity
por: Jennifer Abuzzahab, M, et al.
Publicado: (2023)

SUN-114 Microglia Interact with Hypothalamic Progenitors during Development and Are Required for Proper Energy Balance
por: Rosin, Jessica, et al.
Publicado: (2019)

SAT-602 Hypothalamic P75 Neurotrophin Receptor Regulates Homeostatic Feeding and Food Anticipation
por: Podyma, Brandon, et al.
Publicado: (2020)

SAT656 Weight Reduction After 6 Months Of Setmelanotide Treatment In Patients With Hypothalamic Obesity
por: Roth, Christian L, et al.
Publicado: (2023)

FRI064 The Role Of GLP-1 Receptor Agonists In The Treatment Of Pituitary And Hypothalamic Tumor Induced Obesity
por: Botero Suarez, Carlos S, et al.
Publicado: (2023)

SUN-LB018 Role of BMAL1 in Western Diet-Induced Disruption of Circadian Hypothalamic Feeding Neuropeptides
por: Clemenzi, Matthew, et al.
Publicado: (2019)

Fatty Acids Modify the MicroRNA Content of Exosomes Released by Hypothalamic Astrocytes and the Response of POMC Neurons to These Exosomes
por: Collado-Pérez, Roberto, et al.
Publicado: (2021)

FRI066 Treatment History And Comorbidities Reported By Patients With Hypothalamic Obesity Treated With Setmelanotide In A Phase 2 Trial
por: Roth, Christian L, et al.
Publicado: (2023)

SUN-120 Influences Of Peri-implantation Ozone Exposure And Post-natal High Fat Diet On Energy Balance And Hypothalamic DNA Methylation.
por: Miller, Colette, et al.
Publicado: (2019)

FRI065 Trial Design Of A Double-blind, Randomized, Placebo-controlled, Phase 3 Study Of Setmelanotide In Patients With Hypothalamic Obesity
por: Roth, Christian L, et al.
Publicado: (2023)

SAT-597 Hypothalamic ESR1 Gene Knockdown Elicits Intermittent Decrement in Postprandial Energy Expenditure Associated with Obesity Onset in Female Rhesus Monkeys
por: Willging, Molly, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mt4268mgcn5lefjjdidsssu3n3