PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses

We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although increased circulating mitochondrial DNA (mtDNA) has b...

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Detalles Bibliográficos
Autores principales: Bueno, Marta, Zank, Daniel, Buendia-Roldán, Ivette, Fiedler, Kaitlin, Mays, Brenton G., Alvarez, Diana, Sembrat, John, Kimball, Brian, Bullock, Jordan K., Martin, James L., Nouraie, Mehdi, Kaufman, Brett A., Rojas, Mauricio, Pardo, Annie, Selman, Moisés, Mora, Ana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553779/
https://www.ncbi.nlm.nih.gov/pubmed/31170232
http://dx.doi.org/10.1371/journal.pone.0218003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553779/
https://www.ncbi.nlm.nih.gov/pubmed/31170232
http://dx.doi.org/10.1371/journal.pone.0218003

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