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PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses
We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although increased circulating mitochondrial DNA (mtDNA) has b...
Autores principales: | Bueno, Marta, Zank, Daniel, Buendia-Roldán, Ivette, Fiedler, Kaitlin, Mays, Brenton G., Alvarez, Diana, Sembrat, John, Kimball, Brian, Bullock, Jordan K., Martin, James L., Nouraie, Mehdi, Kaufman, Brett A., Rojas, Mauricio, Pardo, Annie, Selman, Moisés, Mora, Ana L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553779/ https://www.ncbi.nlm.nih.gov/pubmed/31170232 http://dx.doi.org/10.1371/journal.pone.0218003 |
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