A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Purpose: Monitoring response and resistance to 5-azacitidine (AZA) is essential when treating patients with myelodysplastic syndrome (MDS). To quantify methylated DNA not only in the promoter region but also in the gene body, we established a single-molecule methylation assay (SMMA). Patients and me...

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Detalles Bibliográficos
Autores principales: Asano, Michiyo, Ohyashiki, Junko H, Kobayashi-Kawana, Chiaki, Umezu, Tomohiro, Imanishi, Satoshi, Azuma, Kenko, Akahane, Daigo, Fujimoto, Hiroaki, Ito, Yoshikazu, Ohyashiki, Kazuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553951/
https://www.ncbi.nlm.nih.gov/pubmed/31239639
http://dx.doi.org/10.2147/DDDT.S195071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553951/
https://www.ncbi.nlm.nih.gov/pubmed/31239639
http://dx.doi.org/10.2147/DDDT.S195071

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