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A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Purpose: Monitoring response and resistance to 5-azacitidine (AZA) is essential when treating patients with myelodysplastic syndrome (MDS). To quantify methylated DNA not only in the promoter region but also in the gene body, we established a single-molecule methylation assay (SMMA). Patients and me...

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Detalles Bibliográficos
Autores principales:	Asano, Michiyo, Ohyashiki, Junko H, Kobayashi-Kawana, Chiaki, Umezu, Tomohiro, Imanishi, Satoshi, Azuma, Kenko, Akahane, Daigo, Fujimoto, Hiroaki, Ito, Yoshikazu, Ohyashiki, Kazuma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553951/ https://www.ncbi.nlm.nih.gov/pubmed/31239639 http://dx.doi.org/10.2147/DDDT.S195071

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