CAT tails drive degradation of stalled polypeptides on and off the ribosome

Stalled translation produces incomplete, ribosome-tethered polypeptides that the Ribosome-associated Quality Control (RQC) pathway targets for degradation via the E3 ubiquitin ligase Ltn1. During this process, the protein Rqc2 and the large ribosomal subunit elongate stalled polypeptides with carbox...

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Detalles Bibliográficos
Autores principales: Sitron, Cole S., Brandman, Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554034/
https://www.ncbi.nlm.nih.gov/pubmed/31133701
http://dx.doi.org/10.1038/s41594-019-0230-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554034/
https://www.ncbi.nlm.nih.gov/pubmed/31133701
http://dx.doi.org/10.1038/s41594-019-0230-1

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