Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

Given its aggressive tumor biology and its exceptional therapy resistance, pancreatic ductal adenocarcinoma (PDAC) remains a major challenge in cancer medicine and is characterized by a 5-year survival rate of <8%. At the cellular level, PDAC is largely driven by the activation of signaling pathw...

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Detalles Bibliográficos
Autores principales: Hasselluhn, Marie C., Schmidt, Geske E., Ellenrieder, Volker, Johnsen, Steven A., Hessmann, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554303/
https://www.ncbi.nlm.nih.gov/pubmed/31171768
http://dx.doi.org/10.1038/s41419-019-1682-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554303/
https://www.ncbi.nlm.nih.gov/pubmed/31171768
http://dx.doi.org/10.1038/s41419-019-1682-2

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