Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tau(P301L) expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrain region. Unexpectedly, we found that in a diffe...

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Detalles Bibliográficos
Autores principales: Gamache, Julia, Benzow, Kellie, Forster, Colleen, Kemper, Lisa, Hlynialuk, Chris, Furrow, Eva, Ashe, Karen H., Koob, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554306/
https://www.ncbi.nlm.nih.gov/pubmed/31171783
http://dx.doi.org/10.1038/s41467-019-10428-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554306/
https://www.ncbi.nlm.nih.gov/pubmed/31171783
http://dx.doi.org/10.1038/s41467-019-10428-1

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