Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease

Pridopidine is a small molecule in clinical development for the treatment of Huntington’s disease. It was recently found to have high binding affinity to the sigma-1 receptor, a chaperone protein involved in cellular defense mechanisms and neuroplasticity. Here, we have evaluated the neuroprotective...

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Detalles Bibliográficos
Autores principales: Francardo, Veronica, Geva, Michal, Bez, Francesco, Denis, Quentin, Steiner, Lilach, Hayden, Michael R., Cenci, M. Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554374/
https://www.ncbi.nlm.nih.gov/pubmed/30756361
http://dx.doi.org/10.1007/s13311-018-00699-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554374/
https://www.ncbi.nlm.nih.gov/pubmed/30756361
http://dx.doi.org/10.1007/s13311-018-00699-9

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