Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics...

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Detalles Bibliográficos
Autores principales: Haythorne, Elizabeth, Rohm, Maria, van de Bunt, Martijn, Brereton, Melissa F., Tarasov, Andrei I., Blacker, Thomas S., Sachse, Gregor, Silva dos Santos, Mariana, Terron Exposito, Raul, Davis, Simon, Baba, Otto, Fischer, Roman, Duchen, Michael R., Rorsman, Patrik, MacRae, James I., Ashcroft, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554411/
https://www.ncbi.nlm.nih.gov/pubmed/31171772
http://dx.doi.org/10.1038/s41467-019-10189-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554411/
https://www.ncbi.nlm.nih.gov/pubmed/31171772
http://dx.doi.org/10.1038/s41467-019-10189-x

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