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Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts
RNA aptamers and RNA aptamer-based devices can be genetically encoded and expressed in cells to probe and manipulate cellular function. However, their usefulness is limited by low expression and rapid degradation in mammalian cells. Here we describe the Tornado (‘Twister-optimized RNA for durable ov...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554452/ https://www.ncbi.nlm.nih.gov/pubmed/30962542 http://dx.doi.org/10.1038/s41587-019-0090-6 |