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Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts

RNA aptamers and RNA aptamer-based devices can be genetically encoded and expressed in cells to probe and manipulate cellular function. However, their usefulness is limited by low expression and rapid degradation in mammalian cells. Here we describe the Tornado (‘Twister-optimized RNA for durable ov...

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Detalles Bibliográficos
Autores principales: Litke, Jacob L., Jaffrey, Samie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554452/
https://www.ncbi.nlm.nih.gov/pubmed/30962542
http://dx.doi.org/10.1038/s41587-019-0090-6

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