Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. R532H mutation in nsP1 caused reduced infectivity in mouse ta...

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Detalles Bibliográficos
Autores principales: Chan, Yi‐Hao, Teo, Teck‐Hui, Utt, Age, Tan, Jeslin JL, Amrun, Siti Naqiah, Abu Bakar, Farhana, Yee, Wearn‐Xin, Becht, Etienne, Lee, Cheryl Yi‐Pin, Lee, Bernett, Rajarethinam, Ravisankar, Newell, Evan, Merits, Andres, Carissimo, Guillaume, Lum, Fok‐Moon, Ng, Lisa FP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554673/
https://www.ncbi.nlm.nih.gov/pubmed/31015278
http://dx.doi.org/10.15252/emmm.201810092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554673/
https://www.ncbi.nlm.nih.gov/pubmed/31015278
http://dx.doi.org/10.15252/emmm.201810092

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