New UPLC–MS/MS assay for the determination of tamoxifen and its metabolites in human plasma, application to patients

AIM: A rapid UPLC–MS/MS method for the determination of tamoxifen (TAM), N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma was validated, after a simple protein precipitation. MATERIALS AND METHODS: The analysis was achieved on a C(18) analytical column, using a gradient elution...

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Detalles Bibliográficos
Autores principales: Bobin-Dubigeon, Christine, Campone, Mario, Rossignol, Elsa, Salaun, Estelle, Amiand, Marie-Bernadette, Bard, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554689/
https://www.ncbi.nlm.nih.gov/pubmed/31245038
http://dx.doi.org/10.2144/fsoa-2018-0113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554689/
https://www.ncbi.nlm.nih.gov/pubmed/31245038
http://dx.doi.org/10.2144/fsoa-2018-0113

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