OR04-4 Cardiomyocyte Transcription Is Controlled By Combined Mr And Circadian Clock Signalling.

Inappropriate mineralocorticoid receptor (MR) activation promotes cardiac tissue inflammation and fibrosis.We identified a critical pathogenic role for MR activation specifically in cardiomyocytes that revealed a potential interaction between the MR and the molecular circadian clock. While glucocort...

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Detalles Bibliográficos
Autores principales: Fletcher, Elizabeth, Kanki, Monica, Morgan, James, Delbridge, Lea, Ray, David, Fuller, Peter, Clyne, Colin, Young, Morag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Cardiovascular Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554844/
http://dx.doi.org/10.1210/js.2019-OR04-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554844/
http://dx.doi.org/10.1210/js.2019-OR04-4

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