OR12-6 Deletion Of The Brain-Specific α And δ Isoforms Of SH2B1 Protects Against Diet-Induced Obesity In A Leptin-Independent Manner

The scaffold protein SH2B1 plays a critical role in the regulation of energy balance and glucose homeostasis—humans with mutations in SH2B1 are obese and diabetic, as are SH2B1KO mice. The 4 known isoforms of SH2B1 (α, β, γ, δ), which differ only in their C-terminal tails, have distinct expression p...

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Detalles Bibliográficos
Autores principales: Cote, Jessica, Argetsinger, Lawrence, Flores, Anabel, Cline, Joel, DeSantis, Lauren, Bedard, Alexander, Cacciaglia, Abrielle, Clutter, Erik, Myers, Martin, Carter-Su, Christin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Adipose Tissue, Appetite, and Obesity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554851/
http://dx.doi.org/10.1210/js.2019-OR12-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554851/
http://dx.doi.org/10.1210/js.2019-OR12-6

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