OR24-5 Aberrant DNA Methylation in Regulatory Genomic Elements Are Associated with Invasive Behavior of Pituitary Macroadenomas: An Integrative Analysis of Epigenome-Wide Studies

A significant proportion of pituitary tumors (PT) invade adjacent structures. Few putative somatic mutations or copy number alterations have been associated with PT invasiveness. DNA methylation abnormalities in regulatory regions are known to impact gene expression and cancer behavior, but have not...

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Detalles Bibliográficos
Autores principales: Mosella, Maritza, Sabedot, Thais, Malta, Tathiane, Felicella, Michelle, Aho, Todd, Poisson, Laila, deCarvalho, Ana, Noushmehr, Houtan, Rock, Jack, Castro, Ana Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Neuroendocrinology and Pituitary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554889/
http://dx.doi.org/10.1210/js.2019-OR24-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554889/
http://dx.doi.org/10.1210/js.2019-OR24-5

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