OR33-6 The Neurokinin 3 Receptor Antagonist, Fezolinetant, Is Effective in Treatment of Menopausal Vasomotor Symptoms: A Randomized, Placebo-Controlled, Double-Blind, Dose-Ranging Study

Vasomotor symptoms (VMS; eg, hot flashes, night sweats) are caused by a loss of thermoregulatory control. The thermoregulatory center in the brain is innervated by kisspeptin/neurokinin B/dynorphin (KNDy) neurons. The activity of KNDy neurons is stimulated by neurokinin 3 receptor (NK3R) activation...

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Detalles Bibliográficos
Autores principales: Fraser, Graeme, Lederman, Samuel, Waldbaum, Arthur, Lee, Misun, Skillern, Laurence, Ramael, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Reproductive Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554911/
http://dx.doi.org/10.1210/js.2019-OR33-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554911/
http://dx.doi.org/10.1210/js.2019-OR33-6

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