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Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson’s disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of the effects of the environmental toxicant, paraquat, that has...

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Detalles Bibliográficos
Autores principales: Rudyk, Chris, Dwyer, Zach, Hayley, Shawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554960/
https://www.ncbi.nlm.nih.gov/pubmed/31174552
http://dx.doi.org/10.1186/s12974-019-1483-7