Cargando…

NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

BACKGROUND: Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carcinoma (NPC), etc.. In the current study, we intend to illuminate the potential...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Xingguo, Liu, Lisheng, Chang, Minghui, Geng, Xinran, Wang, Xingwu, Wang, Weijun, Chen, Thomas C., Xie, Li, Song, Xianrang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554966/ https://www.ncbi.nlm.nih.gov/pubmed/31174569 http://dx.doi.org/10.1186/s13046-019-1249-1

Ejemplares similares

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation
por: Chang, Minghui, et al.
Publicado: (2018)

Temozolomide–perillyl alcohol conjugate downregulates O(6)-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer
por: Song, Xingguo, et al.
Publicado: (2018)

Circulating exosomes contain protein biomarkers of metastatic non‐small‐cell lung cancer
por: Wang, Ning, et al.
Publicado: (2018)

Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice
por: Cho, Hee-Yeon, et al.
Publicado: (2020)

Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer
por: Song, Xingguo, et al.
Publicado: (2016)

Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer
por: Chang, Minghui, et al.
Publicado: (2022)

Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation
por: Xie, Li, et al.
Publicado: (2015)

TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer
por: Zhang, Zhenyu, et al.
Publicado: (2021)

NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion
por: Marín-Ramos, Nagore I., et al.
Publicado: (2018)

Saliva‐derived cfDNA is applicable for EGFR mutation detection but not for quantitation analysis in non‐small cell lung cancer
por: Ding, Shanshan, et al.
Publicado: (2019)

Pitavastatin Induces Cancer Cell Apoptosis by Blocking Autophagy Flux
por: Tilija Pun, Nirmala, et al.
Publicado: (2022)

Mitochondrial caspase keeps autophagy in flux
por: Short, Ben
Publicado: (2014)

Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy
por: Ding, Shanshan, et al.
Publicado: (2020)

Cytotoxic impact of a perillyl alcohol–temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro
por: Silva-Hirschberg, Catalina, et al.
Publicado: (2019)

Plasma miR‐1247‐5p, miR‐301b‐3p and miR‐105‐5p as potential biomarkers for early diagnosis of non‐small cell lung cancer
por: Dong, Xiaohan, et al.
Publicado: (2020)

Contents in tumor-educated platelets as the novel biosource for cancer diagnostics
por: Zhang, Qianru, et al.
Publicado: (2023)

The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis
por: Luo, Yonghong, et al.
Publicado: (2020)

Plasma exosomal miR-320d, miR-4479, and miR-6763-5p as diagnostic biomarkers in epithelial ovarian cancer
por: Wang, Shiwen, et al.
Publicado: (2022)

Fractionated irradiation induced radio-resistant esophageal cancer EC109 cells seem to be more sensitive to chemotherapeutic drugs
por: Xie, Li, et al.
Publicado: (2009)

Identification of Diagnostic Exosomal LncRNA-miRNA-mRNA Biomarkers in Colorectal Cancer Based on the ceRNA Network
por: Zhao, Yajing, et al.
Publicado: (2022)

Tumor‐educated platelet SNORD55 as a potential biomarker for the early diagnosis of non‐small cell lung cancer
por: Dong, Xiaohan, et al.
Publicado: (2021)

NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity
por: Chen, Thomas C., et al.
Publicado: (2022)

Tumor‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer
por: Niu, Limin, et al.
Publicado: (2018)

Tumor‐educated leukocytes mRNA as a diagnostic biomarker for non‐small cell lung cancer
por: Niu, Limin, et al.
Publicado: (2021)

MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression
por: Song, Bao, et al.
Publicado: (2010)

AB212. Clusterin expression and human testicular seminoma
por: Tang, Min, et al.
Publicado: (2014)

Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia
por: Schönthal, Axel H., et al.
Publicado: (2021)

Plasma SNORD42B and SNORD111 as potential biomarkers for early diagnosis of non‐small cell lung cancer
por: Wang, Kangyu, et al.
Publicado: (2022)

Novel immunomodulatory drugs and neo-substrates
por: Gao, Shaobing, et al.
Publicado: (2020)

Tenovin-6 impairs autophagy by inhibiting autophagic flux
por: Yuan, Hongfeng, et al.
Publicado: (2017)

Search of ligands suitable for (212)Pb/(212)Bi in vivo generators
por: Bartoś, Barbara, et al.
Publicado: (2012)

LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells
por: Guo, Yongjian, et al.
Publicado: (2019)

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells
por: Wasik, A M, et al.
Publicado: (2011)

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy
por: Ucar, Ahmet, et al.
Publicado: (2012)

Tumor-Derived Exosomal miRNAs as Diagnostic Biomarkers in Non-Small Cell Lung Cancer
por: Zhang, Zhijun, et al.
Publicado: (2020)

Tumor‐derived exosomal miRNA‐320d as a biomarker for metastatic colorectal cancer
por: Tang, Youyong, et al.
Publicado: (2019)

Correction: Tenovin-6 impairs autophagy by inhibiting autophagic flux
por: Yuan, Hongfeng, et al.
Publicado: (2018)

Circulating Exosomal miR-150-5p and miR-99b-5p as Diagnostic Biomarkers for Colorectal Cancer
por: Zhao, Ya jing, et al.
Publicado: (2019)

NEO E-vita—NEO era!
por: Jakob, Heinz, et al.
Publicado: (2022)

tRNA‐derived fragments: tRF‐Gly‐CCC‐046, tRF‐Tyr‐GTA‐010 and tRF‐Pro‐TGG‐001 as novel diagnostic biomarkers for breast cancer
por: Zhang, Yue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lt3o6uoeit0l48b5368k38bb0a