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OR10-6 Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis

Traumatic Brain Injury (TBI) is associated with disruption of cerebral blood flow leading to localized brain hypoxia. Thyroid hormone (TH) treatment, when administered shortly after injury, has been shown to promote neural survival in rodent TBI models. The mechanism of TH protection, however, is no...

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Detalles Bibliográficos
Autores principales: Abe, Kiyomi, Li, Jianrong, Milanesi, Anna, Liu, Yan-Yun, Brent, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555015/
http://dx.doi.org/10.1210/js.2019-OR10-6