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OR34-6 A Novel Mechanism of SDH-Deficient Tumorigenesis and Implications for Genetic Testing in Patients with Pheochromocytoma-Paraganglioma
Introduction: Germline mutations in the succinate dehydrogenase genes (SDHA/B/C/D, SDHAF2 - collectively, SDHx) have been implicated in paraganglioma (PGL), renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST) and pituitary adenoma (PA). Negative SDHB tumor staining is indicative of SDH...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrine Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555053/ http://dx.doi.org/10.1210/js.2019-OR34-6 |