OR34-6 A Novel Mechanism of SDH-Deficient Tumorigenesis and Implications for Genetic Testing in Patients with Pheochromocytoma-Paraganglioma

Introduction: Germline mutations in the succinate dehydrogenase genes (SDHA/B/C/D, SDHAF2 - collectively, SDHx) have been implicated in paraganglioma (PGL), renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST) and pituitary adenoma (PA). Negative SDHB tumor staining is indicative of SDH...

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Detalles Bibliográficos
Autores principales: De Sousa, Sunita M.C., Toubia, John, Feng, Jingua, Wang, Paul, Hardy, Tristan S.E., Babic, Milena, Geoghegan, Joel, Hall, Rachel, Scott, Grist, Rawlings, Lesley, Schreiber, Andreas, Luxford, Catherine, Clifton-Bligh, Roderick, Poplawski, Nicola, Scott, Hamish, Torpy, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Tumor Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555053/
http://dx.doi.org/10.1210/js.2019-OR34-6

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