Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy

We previously reported the in vitro selection and characterization of a DNA aptamer capable of stimulating remyelination in a mouse model of multiple sclerosis. This aptamer was selected for its ability to bind to suspensions of crude murine myelin in vitro. Our initial studies in vitro and in vivo...

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Detalles Bibliográficos
Autores principales: Wilbanks, Brandon, Smestad, John, Heider, Robin M., Warrington, Arthur E., Rodriguez, Moses, Maher, L. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555174/
https://www.ncbi.nlm.nih.gov/pubmed/30855209
http://dx.doi.org/10.1089/nat.2018.0776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555174/
https://www.ncbi.nlm.nih.gov/pubmed/30855209
http://dx.doi.org/10.1089/nat.2018.0776

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