Prolonged inhibition of P-glycoprotein after exposure to chemotherapeutics increases cell mortality in multidrug resistant cultured cancer cells

One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance (MDR) phenomenon results in failed therapies and...

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Detalles Bibliográficos
Autores principales: Nanayakkara, Amila K., Vogel, Pia D., Wise, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555590/
https://www.ncbi.nlm.nih.gov/pubmed/31173617
http://dx.doi.org/10.1371/journal.pone.0217940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555590/
https://www.ncbi.nlm.nih.gov/pubmed/31173617
http://dx.doi.org/10.1371/journal.pone.0217940

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