DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with tumor aggressiveness and outcome. What signals and...

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Detalles Bibliográficos
Autores principales: Bayer, Samantha VH, Grither, Whitney R, Brenot, Audrey, Hwang, Priscilla Y, Barcus, Craig E, Ernst, Melanie, Pence, Patrick, Walter, Christopher, Pathak, Amit, Longmore, Gregory D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555593/
https://www.ncbi.nlm.nih.gov/pubmed/31144616
http://dx.doi.org/10.7554/eLife.45508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555593/
https://www.ncbi.nlm.nih.gov/pubmed/31144616
http://dx.doi.org/10.7554/eLife.45508

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