The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

The 3′ poly(A) tail of mRNAs is fundamental to regulating eukaryotic gene expression. Shortening of the poly(A) tail, termed deadenylation, reduces transcript stability and inhibits translation. Nonetheless, the mechanism for poly(A) recognition by the conserved deadenylase complexes, Pan2–Pan3 and...

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Detalles Bibliográficos
Autores principales: Tang, Terence TL, Stowell, James AW, Hill, Chris H, Passmore, Lori A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555765/
https://www.ncbi.nlm.nih.gov/pubmed/31110294
http://dx.doi.org/10.1038/s41594-019-0227-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555765/
https://www.ncbi.nlm.nih.gov/pubmed/31110294
http://dx.doi.org/10.1038/s41594-019-0227-9

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